产品货号：
GS4694
中文名称：
重组小鼠NOV
英文名称：
Recombinant Murine Nephroblastoma-overexpressed Gene Protein Homolog
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 36.4kDa,a single non-glycosylated polypeptide chain containing 333 amino acids.
储存条件：冷冻（-20℃）
概述
NOV is a member of the CCN family of secreted cysteine rich regulatory proteins.The full length NOV protein contains four structural domains that confer distinct,and sometimes opposing,biological activities.Elevated expression of NOV is associated with certain tumors,including Wilm’s tumor and most nephroblastomas.However,in other tumor types and certain cancer cell lines,increased tumorgenicity and proliferation is correlated with decreased NOV expression.Additionally,NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C.NOV has also been reported to exert proangiogenic activities.Recombinant murine NOV is a 36.4 kDa protein containing 333 amino acid residues.It is composed of four distinct structural domains(modules)- the IGF binding protein(IGFBP)domain,the von Willebrand Factor C(VWFC)domain,the Thrombospondin type-I(TSP type-1)domain,and a C-terminal cysteine knot-like domain(CTCK).
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组小鼠NOV，NOV, Murine
储存条件：冷冻（-20℃）
概述
NOV is a member of the CCN family of secreted cysteine rich regulatory proteins.The full length NOV protein contains four structural domains that confer distinct,and sometimes opposing,biological activities.Elevated expression of NOV is associated with certain tumors,including Wilm’s tumor and most nephroblastomas.However,in other tumor types and certain cancer cell lines,increased tumorgenicity and proliferation is correlated with decreased NOV expression.Additionally,NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C.NOV has also been reported to exert proangiogenic activities.Recombinant murine NOV is a 36.4 kDa protein containing 333 amino acid residues.It is composed of four distinct structural domains(modules)- the IGF binding protein(IGFBP)domain,the von Willebrand Factor C(VWFC)domain,the Thrombospondin type-I(TSP type-1)domain,and a C-terminal cysteine knot-like domain(CTCK).
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 1.0μg/ml,corresponding to a specific activity of>1000 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in 20mMTris-HCl,pH 8.6,150 mM NaCl. |
| 内毒素 | Less than 0.1 EU/μg of rMuNOV as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | QVSASLRCPS RCPPKCPSIS PTCAPGVRSV LDGCSCCPVC ARQRGESCSE MRPCDQSSGL YCDRSADPNN QTGICMVPEG DNCVFDGVIY RNGEKFEPNC QYFCTCRDGQ IGCLPRCQLD VLLPGPDCPA PRKVAVPGEC CEKWTCGSDE QGTQGTLGGL ALPAYRPEAT VGVEVSDSSI NCIEQTTEWS ACSKSCGMGV STRVTNRNRQ CEMVKQTRLC IVRPCEQEPE EV |
相关搜索：重组小鼠NOV，NOV, Murine